IIT Hyderabad Develops Affordable Oral Drug To Treat Black Fungus, Tablet Priced At Rs 200
"At present, the Kala-Azar treatment is being used as a treatment for Black & other Fungus in the country and its availability & affordability make it need to allow emergency & immediate trial of this oral drug", read the press release.
Hyderabad: IIT Hyderabad has developed an oral solution to treat Black Fungus (Mucormycosis) and other fungus and are ready to transfer the technology to take it forward, the premier institute said.
In 2019, researchers Prof. Saptarshi Majumdar & Dr. Chandra Shekhar Sharma from the Department of Chemical Engineering made a proven study about oral nanofibrous AMB to be effective for Kala Azar.
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"At present, the Kala-Azar treatment is being used as a treatment for Black & other Fungus in the country and its availability & affordability make it need to allow emergency & immediate trial of this oral drug", read the press release.
A 60-mg tablet, which can be priced at about Rs 200, is patient friendly as its slow and sustained release in the body reduces nephrotoxicity (adverse impact of medicines and chemicals on the kidney.
The technology developed is made free from Intellectual Property rights so that it can be mass-produced and is affordable and available to the public at large, Dr.Chandra Shekhar Sharma said.
How it works:
Due to its amphiphilic nature, the AmB has poor aqueous solubility and forms aggregates in the system, which stresses renal filtration and thus causing nephrotoxicity. This is the reason the oral administration has abstained, although being the most comfortable and effective route. In present research funded by DST-Nanomission, a team led by Prof. Saptarshi Majumdar and Dr. Chandra Shekhar Sharma along with their PhD scholars Mrunalini Gaydhane and Anindita Laha intended to deliver Amphotericin B orally at an extremely slow rate, of course within the therapeutic window. The release further explained, that the purpose was to increase the drug absorption and reduce aggregation, to lower the drug toxicity. For this, the team has selected gelatin an FDA-approved polymer as an excipient for drug molecules.
As gastrointestinal tract contains different enzymes which hydrolyze the polymers, the team has also checked and confirmed the enzymatic stability of tablet in pepsin. The significance of the nanofibrous tablets is depicted in the enclosed illustration. The main concern with high drug loading was if it imposes nephrotoxicity. To ensure this, the team has carried out a cell viability assay (MTT assay) against human kidney fibroblast cells which illustrated no evidence of cell toxicity caused by AmB as well as a minute amount of Glutaraldehyde crosslinker
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