Possible cause for Alzheimer's, traumatic brain injury identified

Under conditions of stress in a brain affected by Alzheimer's, KCNB1 builds up and becomes toxic to neurons and then promotes the production of amyloid-beta.

Researchers have identified a new mechanism that may contribute to Alzheimer's disease and traumatic brain injury, hoping that the discovery may lead to effective treatment. (AFP)

New York: Researchers have identified a new mechanism that may contribute to Alzheimer's disease and traumatic brain injury, hoping that the discovery may lead to effective treatment. According to researchers from Rutgers University, the causes of Alzheimer's is unknown. But a popular theory suggests a protein known as amyloid-beta slowly builds up a plaque in the brains of people with the disease. The research team looked at a new mechanism, which involves a non-amyloid-beta protein, a potassium channel referred to as KCNB1. Under conditions of stress in a brain affected by Alzheimer's, KCNB1 builds up and becomes toxic to neurons and then promotes the production of amyloid-beta. The build-up of KCNB1 channels is caused by a chemical process commonly known as oxidation. "Indeed, scientists have known for a long time that during aging or in neurodegenerative disease cells produce free radicals," said co-author Federico Sesti, a professor at the varsity. "Free radicals are toxic molecules that can cause a reaction that results in lost electrons in important cellular components, including the channels," Sesti added. The study, published in the journal Cell Death and Disease, found that in brains affected by Alzheimer's, the build-up of KCNB1 was much higher compared to normal brains. "The discovery of KCNB1's oxidation/build-up was found through observation of both mouse and human brains, which is significant as most scientific studies do not usually go beyond observing animals," said Sesti. "Further, KCBB1 channels may not only contribute to Alzheimer's but also to other conditions of stress as it was found in a recent study that they are formed following brain trauma," Sesti added. In the cases of Alzheimer's and traumatic brain injury, the build-up of KCNB1 is associated with severe damage of mental function. As a result of this discovery, the researcher successfully tested a drug called Sprycel in mice. The drug is used to treat patients with leukemia. The research team now hopes to launch a clinical trial to test the treatment in humans.