Amir will be Karachi’s fourth captain in the tournament, with England skipper Eoin Morgan also leading the line in Imad’s absence in the last couple of games.
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Karachi have had terrible luck with their skippers in previous editions as well, with former skipper Shoaib Malik once resigning in the middle of a campaign.
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But on Wednesday afternoon, it came to light that Afridi too will not be able to take the field because of an injury.
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Pakistan Super League franchise Karachi Kings received a huge blow hours before their eliminator encounter against Peshawar Zalmi.
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Amir, who has been leading the new ball attack for Karachi, will take over as captain for the all-important match.
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Left-arm fast bowler Mohammed Amir was given the responsibility to solve the leadership puzzle.
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With Karachi captain Imadi Wasim already out of the contest with a head injury, the responsibility was on seasoned campaigner Shahid Afridi to lead the charge.