Australia's stellar win came on the back of breezy centuries by hard hitting batsman Glen Maxwell and wicket-keeper batsman Alex Carey who helped the visitors chase down a herculean 303-run target.
Australia's chase looked all but over after they were reeling at 73 for 5 but Maxwell and Carey staged a brilliant comeback courtesy a record 212 run stand to help their team cross the finishing line.
While Maxwell smashed seven sixes and four boundaries to score his fiery ton (108) and bring up 3000 ODI runs, Alex Carey got back to form eventually with his maiden hundred (106) that came at just the right time for the Aaron Finch led side.
Australia were in all sorts of bother when seamer Chris Woakes struck early to dismiss skipper Aaron Finch and Marcus Stoinis before part time spinner Root dismissed opener David Warner for 24. When Marnus Labuschange was run out needlessly and Mitchell Marsh scalped by Root, the visitors were tottering at 73 for 5.
ALSO READ | ENG vs AUS, 2nd ODI: Hosts Level Series After Australia Suffer Dramatic Collapse At Manchester
Earlier in the match, England posted a challenging 302-7 on the board riding high on a ton by their wicket-keeper batsman Jonny Bairstow. After Mitchell Starc rattled the English top order dismissing both opener Jason Roy and skipper Joe Root for a duck, leaving the host stunned at 0 for 2, Bairstow resurrected the innings by stitching handy partnerships with half centurions Sam Billings and Chris Woakes to help England post a competitive target.
Glen Maxwell was awarded both the man of the match and the series for his outstanding all-round efforts with bat and ball for the Australians.