The Indo-Serbian pair were sent packing from the grand slam after losing 4-6, 6-3, 3-6 against 8th seeds Nikola Mektic and Wesley Koolhof in the men's doubles second round clash played on Wednesday.
Ranked 58th on the ATP Men's Doubles rankings Divij Sharan, and Nikola Cacic did not get off to the best possible starts losing the opening set 4-6 but got back into the contest by clinching the second set and forcing a third and final decider to the match.
However, inconsistent serving proved to be the nemesis of the Indo-Serb duo in the final set and they made a tame surrender to Mektic and Koolhof in the final set.
Earlier, Divij Sharan played his first competitive tournament after a Covid-19 induced break by partnering with Robin Haase at the Prague Challenger ahead of the UP Open.
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India's top-ranked doubles player Rohan Bopanna and his Canadian partner Denis Shapovalov will get their men's doubles campaign underway on Thursdasy when they take on American duo Noah Rubin and Ernesto Escobedo.
Earlier on Tuesday, Sumit Nagal became the first Indian men's singles player to win a Grand Slam main draw match since Somdev Devvarman in 2013.
Nagal defeated USA's Bradley Klahn in a 4-set opening round encounter to set up a tough clash with second seed Austrian Dominic Thiem.