Shankar suffered the injury after being hit on toe during India's training session. A Jasprit Bumrah yorker hit him flush on his toes and he was apparently in pain.
The 28-year-old received maiden call for the World Cup 2019 ahead of the likes of Ambati Rayudu and Ajinkya Rahane as the selectors relied upon his ‘three-dimensional qualities’.
"Vijay got hit on the toe by a Jasprit Bumrah delivery once again. His situation is not great and he won't be able to take part in the tournament. He is going back home," a senior BCCI official told PTI.
"The Indian team management is likely to ask for Mayank Agarwal as replacement since he is an opener and also it might give KL Rahul a chance to get back to the No.4 position in case Rishabh Pant fails in the next two games," the source added.
In fact, Rohit Sharma had mentioned Shankar's injury but it was presumed to be an old hit that he took at Southampton.
It is expected that Agarwal's name will be approved by the ICC's tournament technical committee and the player will arrive in Birmingham and travel to Leeds subsequently.
Vijay Shankar has been in dismal form when it comes to bat in this World Cup, The all-rounder has highest score of just 29, he attained against ‘underdogs’ Afghanistan in India's last group match.
India lost their previous match to England by 31 runs here on Sunday and will take on Bangladesh at the same venue on Tuesday.