The spokesman said, "On the advice of his medical team, the PM will not be immediately returning to work. He wishes to thank everybody at St Thomas' for the brilliant care he has received".
Earlier in the day, Johnson thanked the medics and staff of the state-funded National Health Service (NHS) for saving his life after he tested positive for the Coronavirus, saying he owed them his life.
Thousands of get-well-soon cards have also flooded in for the prime minister since he went into self-isolation after testing positive for Coronavirus over two weeks ago.
The Prime Minister was taken to St Thomas' Hospital in central London last Sunday with constant COVID-19 symptoms.
On Monday the 55-year-old was taken into intensive care but after three nights was relocated back to the general ward.
He will now spend time recovering at Chequers, the Prime Minister's grace and favour country manor in Buckinghamshire.
The spokesman said, “The PM has been discharged from hospital to continue his recovery, at Chequers".
Boris Johnson, 55, was diagnosed over two weeks ago, becoming the first world leader confirmed to have the illness from the novel Coronavirus.
His Coronavirus symptoms at first were said to have been mild, including cough and a fever, and he was working from home during the first few days.
The five worst-affected countries which have remained constant in the past week, UK has emerged as the country with the fastest growth in new additions of Coronavirus infections.
On 10th April, UK saw a massive rise in confirmed COVID-19 cases as it added 8,681 cases in a single day taking its tally closer to 79,000.