Bopanna and his Canadian partner, seeded seventh, shocked third seeds Andrea Hlavackova and Edouard Roger-Vasselin 7-5 6-3 in the semifinals.
This is only the second time in his career that Bopanna had reached the summit clash of a Grand Slam. In 2010, he had made the final of US Open men's doubles with Pakistani partner Aisam-ul-haq-Qureshi and lost to legendary Bryan brothers -- Bob and Mike.
They will now fight it out with Germany's Anna-Lena Groenefeld and Colombia's Robert Farah, who knocked out Casey Dellacqua and Rajeev Ram 6-7(5) 6-3 10-5 in other semifinal contest.
Only three Indians have so far managed to lay hands on a Grand Slam trophy -- the legendary Leander Paes, Mahesh Bhupathi and Sania Mirza.
Bopanna is the lone Indian to survive in the tournament after the exits of Paes and Sania.