The driver, Noor Mohammed Dar, 42, was rushed to a nearby district hospital, from where he was referred to Sher-e-Kashmir Institute of Medical Sciences at Soura in the outskirts of Srinagar where he was declared brought dead.
The arrested youths were being questioned to ascertain their motive behind the crime, police said, adding that the duo had no past criminal history.
It is alleged that the miscreants mistook his truck for a security force vehicle and hurled stones at it, police said, adding a stone hit the windscreen and injured Dar in the head.
A few days ago, a girl was seriously injured in a stone-pelting incident in downtown city of Srinagar.
(With additional information from PTI)