The four members of the family, including two children, were sleeping on the first floor and after they saw smoke emanating from downstairs they tried to escape but were suffocated to death.
The fire reportedly broke out in the stilt parking of the four-storeyed building.
Three others were injured, in the tragedy.
A call was received at 2.48 am about a fire in the parking area and 10 fire tenders were rushed to the spot. The fire was doused by around 4 am, a fire department official said.
ANI tweeted to inform about the incident.: " 4 dead after a fire broke out in a house in Kohat Enclave allegedly due to a short circuit. Further investigation underway."