The flick collected Rs 10.05 crores on Friday, Rs 16.42 crores on Saturday and Rs 18.10 crores on Sunday making the total to Rs 44.57 crores.
The film fared better than 'Raazi' which raked in Rs 32. 94 crores, 'Stree' 32.27 crores and 'Uri: The Surgical Strike' minted Rs 35.73 crores over the weekend.
Film critic and trade analyst Taran Adarsh shared the numbers on his Twitter handle.
The film in which the 'Vicky Donor' actor can be seen pretending as a seductive tele-caller Pooja, emerged as the biggest opener of Ayushmann till date.
Taran also gave a brief account of all the weekend collections of Ayushmann's films and how 'Dream Girl' stands first on the list of the biggest collector. "Opening Weekend* biz: 2019: #DreamGirl Rs 44.57 cr.. 2018: #BadhaaiHo Rs 45.70 cr [extended 4-day wknd]... 2019: #Article15 Rs 20.04 cr... 2018: #AndhaDhun Rs 15 cr... 2017: #ShubhMangalSaavdhan Rs 14.46 cr
2017: #BareillyKiBarfi Rs 11.52 cr," he tweeted.
Ever since the makers unveiled the poster of the film, fans expressed eagerness to watch the star act like a woman on the silver screen.
In the poster, the National Award recipient can be seen sitting on a scooter wearing a yellow coloured saree over a white tee with a set of bangles and rubber slippers.
Apart from Ayushmann, Anu Kapoor is seen playing the role of the lead actor's father while Nushrat Bharucha is seen romancing the actor. Backed by Ekta Kapoor, the film is being helmed by Raaj Shaandilyaa.
The film had hit the screens on September 13.