The Proteas were then 14 without loss in the fourth over chasing 312 to win on an Oval ground where Amla made a South Africa record 311 not out in a Test against England in 2012.
It was uncertain whether Amla would bat again in the innings, with a statement issued by Cricket South Africa on their Twitter feed saying: "@amlahash has been assessed and is doing fine."
It added: "Due to the sensitive nature of head injuries, he will undergo another reassessment during the course of the innings which will give an indication of his further participation in the match."
However, despite all the effort by South Africa batsmen, England were off to a winning start as their star speedster Jofra Archer bagged three wickets, while Plunkett and Stokes get two each to help the hosts beat South Africa by 104 runs.