This came just hours after it was reported that the NBA player was drunkenly removed from a flight from Los Angeles to New York, reports the Mirror.
A twitter user said the 32-year-old reality star 'needs to be helping her husband' instead of 'running the streets'.
Khloe did not take it well and blasted in response, saying, "Stay in your f***ing lane little girl. You know nothing about anything. You're a sheep herded by society."
There were even some who showered supportive messages on the reality star after she tweeted a sad emoji.
"It's out of your hands Khloe", wrote one.
"You're doing what you can, unfortunately he makes his own choices. Stay strong", another wrote.
Reportedly Odom was spotted drinking whiskey and beer at the airline lounge before takeoff.
Despite the fact the 36-year-old basketball player and Khloe were not together at the time, she took on the role of primary carer during his recovery, including renting a 25,000 dollars home for him just blocks from hers.
Even on the most recent episode of 'Keeping Up With The Kardashians', less than 48 hours before reports surfaced about Odom's drunken plane antics, the 'Kocktails with Khloe' star voiced her disapproval of his 'drinking' and 'smoking'.