The Life OK show will go off air on March 17.
"I am going to miss everyone. The character of Ambika and Devika will always remain close to my heart, just like earlier ones," actress Aparna Dixit said in a statement.
"My journey has been amazing with the cast, production team and Ekta ma'am. But everyone has to move on. I am looking forward to work with her again," she added.
The story of the show will conclude on a happy note. Devika (Aparna) will step forward to save her husband Ravi (Krip Suri) and will prove him innocent.The makers of the show have planned a small after-party on the sets.
The show, which started in March 2015, featured actors like Dolly Sohi, Shritama Mukherjee, Priyanka Purohit and Mahesh Shetty.